Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases.

Lipton, Allan; Steger, Guenther; Figueroa, Jazmin; Alvarado, Cristina; Solal-Celigny, Philippe; Body, Jean-Jacques; De Boer, Richard; Berardi, Rossana; Gascon, Pere; Tonkin, Katia; Coleman, Robert; Paterson, Alexander H. G.; Peterson, Mark C.; Fan, Michelle; Kinsey, Amy C.; Jun, Susie

doi:doi/10.1200/JCO.2007.11.8604

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Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases.

par Lipton, Allan ;Steger, Guenther ;Figueroa, Jazmin ;Alvarado, Cristina ;Solal-Celigny, Philippe ;Body, Jean-Jacques

;De Boer, Richard ;Berardi, Rossana ;Gascon, Pere ;Tonkin, Katia ;Coleman, Robert ;Paterson, Alexander H. G.;Peterson, Mark C.;Fan, Michelle ;Kinsey, Amy C.;Jun, Susie
Référence Journal of clinical oncology, 25, 28, page (4431-4437)
Publication Publié, 2007-10

Article révisé par les pairs

Résumé :

Denosumab, a fully human monoclonal antibody to receptor activator of nuclear factor-kappaB ligand, suppresses bone resorption. In this study, we evaluated the efficacy and safety of five dosing regimens of denosumab in patients with breast cancer-related bone metastases not previously treated with intravenous bisphosphonates (IV BPs).

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