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De Novo Synthesis of 1,4-Dihydropyridines and Pyridines

par gati, Wafa;Rammah, M. Mohamed;Rammah, B. Mohamed;Couty, François;Evano, Gwilherm
Référence Journal of the American Chemical Society
Publication Publié, 2012

Article révisé par les pairs

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Résumé :

An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl-ynamides.