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An unusual case of severe combined immunodeficiency with hypereosinophilia

par Dams, Th;Mascart, Françoise ;Schandené, Liliane ;Van Der Meer, J. M W
Référence Journal of internal medicine, 242, 3, page (267-269)
Publication Publié, 1997-09

Article révisé par les pairs

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Résumé :

Dams ETHM, Mascart-Lemone F, Schandené L, van der Meer JWM (University Hospital Nijmegen, Nijmegen, The Netherlands, and Hôpital Erasme, Brussels, Belgium). An unusual case of severe combined immunodeficiency with hypereosinophilia (Case Report). J Intern Med 1997; 242: 267–9.Investigation of the cytokine profile in a 26-year-old man, suffering from combined immunodeficiency with hypereosinophilia, revealed high levels of interleukin-4 and interleukin-5 and relatively low levels of interleukin-2 and interferon gamma, consistent with a T-helper type 2 pattern, as has been reported in Omenn's syndrome. However, some distinct clinical and immunological features suggest that this case may represent a unique disease with specific pathogenesis.