• Citer

Continuous-flow UVC irradiation: A new, effective, protein activity-preserving system for inactivating bacteria and viruses, including erythrovirus B19

par Caillet Fauquet, Perrine ;Di Giambattista, Mario;Draps, Marie-Louise ;Sandras, FLAVIENNE ;Branckaert, Theo;De Launoit, Yvan ;Kupersztejn, Ruth
Référence Journal of virological methods, 118, 2, page (131-139)
Publication Publié, 2004-06

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

Despite the increasing number of screening tests being introduced, ensuring the inactivation of blood-borne pathogens in blood-derived therapeutic material is a major concern. Dynamic continuous-flow UVC irradiation is a new way to inactivate a large range of pathogens without adding any photosentizers. The efficacy of different methods was evaluated against the following viruses: murine parvovirus MVMp, human B19, the encephalomyocarditis virus (EMC, a picornavirus used as a model for model for hepatitis A virus), and bovine herpes virus type 1 (BHV, a model for enveloped viruses such as hepatitis B virus). We show that continuous-flow UVC irradiation is very effective, particularly against resistant pathogens (e.g. parvoviruses and bacteria) at UVC doses preserving protein activity. It may be applicable to newly emerging related viruses or variants. © 2004 Elsevier B.V.