Multifactorial approach to predicting resistance to anthracyclines.

Desmedt, Christine; Di Leo, Angelo; de Azambuja, Evandro; Larsimont, Denis; Haibe-Kains, Benjamin; Selleslags, Jean; Delaloge, Suzette; Duhem, Caroline; Kains, Jean-Pierre; Carly, Birgit; Maerevoet, Marie; Vindevoghel, Anita; Rouas, Ghizlane; Lallemand, Françoise; Durbecq, Virginie; Cardoso, Fatima; Salgado, Roberto; Kraft Rovere, Rodrigo; Bontempi, Gianluca; Michiels, Stefan; Buyse, Marc; Nogaret, Jean-Marie; Qi, Yuan; Symmans, Fraser; Pusztai, Lajos; D'Hondt, Veronique; Piccart-Gebhart, Martine; Sotiriou, Christos

doi:doi/10.1200/JCO.2010.31.2231

Recherche avancée | Historique de recherche Mon DI-fusion | À propos de DI-fusion | Contact |

Citer

Article révisé par les pairs

Résumé :

Validated biomarkers predictive of response/resistance to anthracyclines in breast cancer are currently lacking. The neoadjuvant Trial of Principle (TOP) study, in which patients with estrogen receptor (ER) -negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to evaluate the predictive value of topoisomerase II-α (TOP2A) and develop a gene expression signature to identify those patients who do not benefit from anthracyclines.

Documents en relation

DI-fusion

Identification of HER2-positive breast cancer molecular subtypes with potential clinical implications in the ALTTO clinical trial
par Rediti, Mattia , Venet, David , Joaquin Garcia, Andrea , Maetens, Marion M. , Vincent, Delphine , Majjaj, Samira , El-abed, Sarra , Di Cosimo, Serena , Ueno, Takayuki , Izquierdo, Miguel , Piccart-Gebhart, Martine , Pusztai, Lajos , Loi, Sherene , Salgado, Roberto , Viale, Giuseppe , Rothé, Françoise , Sotiriou, Christos
Publication 2024-12-01
Spatial transcriptomics reveals substantial heterogeneity in triple-negative breast cancer with potential clinical implications.
par Wang, Xiaoxiao , Venet, David , Lifrange, Frédéric , Larsimont, Denis , Rediti, Mattia , Stenbeck, Linnea , Dupont, Floriane , Rouas, Ghizlane , Garcia, Andrea Joaquin , Craciun, Ligia , Buisseret, Laurence , Ignatiadis, Michail , Carausu, Marcela , Bhalla, Nayanika , Masarapu, Yuvarani , Villacampa, Eva Gracia , Franzén, Lovisa , Saarenpää, Sami , Kvastad, Linda , Thrane, Kim , Lundeberg, Joakim , Rothé, Françoise , Sotiriou, Christos
Publication 2024-11
On many-objective feature selection and the need for interpretability
par Njoku, Uchechukwu U.F. , Abelló, Alberto , Bilalli, Besim , Bontempi, Gianluca
Publication 2025-04
The long and winding road to biomarkers for immunotherapy: a retrospective analysis of samples from patients with triple-negative breast cancer treated with pembrolizumab
par Buisseret, Laurence , Bareche, Yacine , Venet, David , Girard, Edwina , Gombos, Andrea , Emonts, Patrick , Majjaj, Samira , Rouas, Ghizlane , Serra, Matteo , Debien, Véronique , Agostinetto, Elisa , Garaud, Soizic , Willard-Gallo, Karen , Larsimont, Denis , Stagg, John , Rothé, Françoise , Sotiriou, Christos
Publication 2024-05-01
Optimizing treatment for HER2-positive HR-positive breast cancer
par Debien, Véronique , de Azambuja, Evandro , Piccart-Gebhart, Martine
Publication 2023-04-01

Référencement	Visibilité	Pérennité	Facilité
Les publications encodées constituent la bibliographie académique de l'Université.	Les documents déposés sont indexés par les moteurs de recherche (Google Scholar,…).	Les documents déposés en open-access sont archivés au sein du réseau de préservation SAFE-PLN (www.safepln.org).	Les listes de publications sont compatibles avec le CV-ULB, le FNRS et accessibles sur le web.