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Antibodies to the constitutive 73-kd heat shock protein: A new marker of mixed connective tissue disease?

par Mairesse, Nicole ;Kahn, M.F.;Appelboom, Thierry
Référence The American journal of medicine, 95, 6, page (595-600)
Publication Publié, 1993

Article révisé par les pairs

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Résumé :

PURPOSE, PATIENTS, AND METHODS: This report documents the finding of an elevated titer of IgG reacting with the constitutive bovine 73-kd heat shock protein (HSP) in the serum of patients with rheumatoid arthritis, scleroderma, and mixed connective tissue disease (MCTD). RESULTS AND CONCLUSIONS: Further characterization of antibodies from patients with MCTD showed that the antibodies also recognize the human constitutive 73-kd HSP, but not the inducible 72-kd isoform. Very high levels of antibodies appeared to be specific for MCTD; the differences between levels in patients with MCTD and those in healthy subjects (blood donors) were highly significant (p <10-8), with no values in this group of patients overlapping with those in the controls. This parameter might therefore represent a new diagnostic marker for this disease.