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Occurrence of putative virulence genes in Arcobacter species isolated from humans and animals.

par Douidah, Laid;de Zutter, Lieven;Baré, Julie;De Vos, Paul;Vandamme, Peter;Vandenberg, Olivier ;Van den Abeele, Anne-Marie;Houf, Kurt
Référence Journal of clinical microbiology, 50, 3, page (734-741)
Publication Publié, 2011-12

Article révisé par les pairs

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Résumé :

Interest for arcobacters in veterinary and human public health has increased since the first report of the isolation of arcobacters from food of animal origin. Since then, studies worldwide have reported the occurrence of arcobacters on food and in food-production animals and have highlighted the possible transmission of especially A. butzleri to the human population. In humans, arcobacters are associated with enteritis and septicemia. To assess their clinical relevance for humans and animals, evaluation of potential virulence factors is required. However, up to now, little is known about the mechanisms of pathogenicity. Because of their close phylogenetic affiliation to the foodborne pathogen Campylobacter and their similar clinical manifestations, the presence of nine putative Campylobacter virulence genes (cadF, ciaB, cj1349, hecA, hecB, irgA, mviN, pldA, tlyA) previously identified in the recent Arcobacter butzleri ATCC 49616 genome sequence, was determined in a large set of human and animal Arcobacter butzleri, Arcobacter cryaerophilus and Arcobacter skirrowii strains after development of rapid and accurate PCR-assays and confirmed by sequencing and dot-blot hybridization.