Titre :
  • 4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.
Auteur : Sebille, Sophie ; de Tullio, Pascal ; Becker, Bénédicte ; Antoine, Marie-Hélène ; Boverie, Stéphane ; Pirotte, Bernard ; Lebrun, Philippe
Informations sur la publication : Journal of medicinal chemistry, 48, 2, (page 614-621)
Statut de publication : Publié, 2005-01
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Animals
Aorta, Thoracic -- drug effects
Aorta, Thoracic -- physiology
Chromans -- chemical synthesis
Chromans -- chemistry
Chromans -- pharmacology
Cromakalim -- chemistry
Cromakalim -- pharmacology
Insulin -- secretion
Ion Channel Gating -- drug effects
Islets of Langerhans -- drug effects
Islets of Langerhans -- secretion
Muscle, Smooth, Vascular -- drug effects
Muscle, Smooth, Vascular -- physiology
Potassium Channels -- drug effects
Potassium Channels -- physiology
Rats
Rats, Wistar
Structure-Activity Relationship
Vasodilator Agents -- chemical synthesis
Vasodilator Agents -- chemistry
Vasodilator Agents -- pharmacology
Note : In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm040789e
info:pmid/15658874