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4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.

par Sebille, Sophie;de Tullio, Pascal;Becker, Bénédicte ;Antoine, Marie-Hélène ;Boverie, Stéphane;Pirotte, Bernard;Lebrun, Philippe
Référence Journal of medicinal chemistry, 48, 2, page (614-621)
Publication Publié, 2005-01

Article révisé par les pairs

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Titre:	4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.
Auteur:	Sebille, Sophie; de Tullio, Pascal; Becker, Bénédicte; Antoine, Marie-Hélène; Boverie, Stéphane; Pirotte, Bernard; Lebrun, Philippe
Informations sur la publication:	Journal of medicinal chemistry, 48, 2, page (614-621)
Statut de publication:	Publié, 2005-01
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Aorta, Thoracic -- drug effects
	Aorta, Thoracic -- physiology
	Chromans -- chemical synthesis
	Chromans -- chemistry
	Chromans -- pharmacology
	Cromakalim -- chemistry
	Cromakalim -- pharmacology
	Insulin -- secretion
	Ion Channel Gating -- drug effects
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- secretion
	Muscle, Smooth, Vascular -- drug effects
	Muscle, Smooth, Vascular -- physiology
	Potassium Channels -- drug effects
	Potassium Channels -- physiology
	Rats
	Rats, Wistar
	Structure-Activity Relationship
	Vasodilator Agents -- chemical synthesis
	Vasodilator Agents -- chemistry
	Vasodilator Agents -- pharmacology
Note générale:	In Vitro
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm040789e
	info:scp/12344332491
	info:pmid/15658874