Titre :
  • Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
Auteur : Lesueur-Ginot, L ; Demarquay, D ; Kiss, Robert ; Kasprzyck, P G ; Dassonville, L ; Bailly, C ; Camara, Javier ; Bigg, D C
Informations sur la publication : Cancer research, 59, 12, (page 2939-2943)
Statut de publication : Publié, 1999-06
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Animals
Antineoplastic Agents -- chemistry
Antineoplastic Agents -- metabolism
Antineoplastic Agents -- therapeutic use
Camptothecin -- analogs & derivatives
Camptothecin -- chemistry
Camptothecin -- pharmacology
Cell Division -- drug effects
DNA -- drug effects
DNA -- metabolism
DNA Topoisomerases, Type I -- antagonists & inhibitors
Disease Models, Animal
Drug Screening Assays, Antitumor
Drug Stability
Enzyme Inhibitors -- chemistry
Enzyme Inhibitors -- metabolism
Enzyme Inhibitors -- therapeutic use
HT29 Cells
Humans
K562 Cells
Lactones -- metabolism
Leukemia L1210 -- drug therapy
Leukemia, Experimental -- drug therapy
Neoplasm Transplantation
Transplantation, Heterologous
Tumor Cells, Cultured
Note : Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0008-5472 
info:pmid/10383158