• Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
Auteur:Lesueur-Ginot, L; Demarquay, D; Kiss, Robert; Kasprzyck, P G; Dassonville, L; Bailly, C; Camara, Javier; Bigg, D C
Informations sur la publication:Cancer research, 59, 12, page (2939-2943)
Statut de publication:Publié, 1999-06
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Animals
Antineoplastic Agents -- chemistry
Antineoplastic Agents -- metabolism
Antineoplastic Agents -- therapeutic use
Camptothecin -- analogs & derivatives
Camptothecin -- chemistry
Camptothecin -- pharmacology
Cell Division -- drug effects
DNA -- drug effects
DNA -- metabolism
DNA Topoisomerases, Type I -- antagonists & inhibitors
Disease Models, Animal
Drug Screening Assays, Antitumor
Drug Stability
Enzyme Inhibitors -- chemistry
Enzyme Inhibitors -- metabolism
Enzyme Inhibitors -- therapeutic use
HT29 Cells
K562 Cells
Lactones -- metabolism
Leukemia L1210 -- drug therapy
Leukemia, Experimental -- drug therapy
Neoplasm Transplantation
Transplantation, Heterologous
Tumor Cells, Cultured
Note générale:Comparative Study
Journal Article
Research Support, Non-U.S. Gov't