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Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.

par Lesueur-Ginot, L;Demarquay, D;Kiss, Robert ;Kasprzyck, P G;Dassonville, L;Bailly, C;Camara, Javier;Bigg, D C
Référence Cancer research, 59, 12, page (2939-2943)
Publication Publié, 1999-06

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Titre:	Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
Auteur:	Lesueur-Ginot, L; Demarquay, D; Kiss, Robert; Kasprzyck, P G; Dassonville, L; Bailly, C; Camara, Javier; Bigg, D C
Informations sur la publication:	Cancer research, 59, 12, page (2939-2943)
Statut de publication:	Publié, 1999-06
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Antineoplastic Agents -- chemistry
	Antineoplastic Agents -- metabolism
	Antineoplastic Agents -- therapeutic use
	Camptothecin -- analogs & derivatives
	Camptothecin -- chemistry
	Camptothecin -- pharmacology
	Cell Division -- drug effects
	DNA -- drug effects
	DNA -- metabolism
	DNA Topoisomerases, Type I -- antagonists & inhibitors
	Disease Models, Animal
	Drug Screening Assays, Antitumor
	Drug Stability
	Enzyme Inhibitors -- chemistry
	Enzyme Inhibitors -- metabolism
	Enzyme Inhibitors -- therapeutic use
	HT29 Cells
	Humans
	K562 Cells
	Lactones -- metabolism
	Leukemia L1210 -- drug therapy
	Leukemia, Experimental -- drug therapy
	Neoplasm Transplantation
	Transplantation, Heterologous
	Tumor Cells, Cultured
Note générale:	Comparative Study
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0008-5472
	info:pmid/10383158