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Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.

par Delfourne, Evelyne;Kiss, Robert ;Le Corre, Laurent;Dujols, Frederic;Bastide, Jean;Collignon, Françoise;Lesur, Brigitte;Frydman, Armand;Darro, Francis
Référence Bioorganic & medicinal chemistry, 12, 15, page (3987-3994)
Publication Publié, 2004-08

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Titre:	Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.
Auteur:	Delfourne, Evelyne; Kiss, Robert; Le Corre, Laurent; Dujols, Frederic; Bastide, Jean; Collignon, Françoise; Lesur, Brigitte; Frydman, Armand; Darro, Francis
Informations sur la publication:	Bioorganic & medicinal chemistry, 12, 15, page (3987-3994)
Statut de publication:	Publié, 2004-08
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Ascididemin
	Marine alkaloids
	Meridine
	Pyridoacridine
MeSH keywords:	Acridines -- chemistry
	Alkaloids -- chemical synthesis
	Alkaloids -- pharmacology
	Antineoplastic Agents -- chemical synthesis
	Antineoplastic Agents -- pharmacology
	Cell Division -- drug effects
	Cell Line, Tumor
	Drug Design
	Drug Screening Assays, Antitumor
	Heterocyclic Compounds with 4 or More Rings -- chemical synthesis
	Heterocyclic Compounds with 4 or More Rings -- pharmacology
	Humans
	Molecular Structure
	Phenanthrolines -- chemical synthesis
	Phenanthrolines -- chemistry
	Phenanthrolines -- pharmacology
	Quinolines -- pharmacology
	Structure-Activity Relationship
Note générale:	Journal Article
Langue:	Anglais
Identificateurs:	urn:issn:0968-0896
	info:doi/10.1016/j.bmc.2004.06.006
	info:pii/S0968089604004225
	info:scp/3042793405
	info:pmid/15246075