Article révisé par les pairs
Titre:
  • Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Auteur:Lamoral-Theys, Delphine; Andolfi, Anna; Van Goietsenoven, Gwendoline; Cimmino, Alessio; Le Calve, Benjamin; Wauthoz, Nathalie; Megalizzi, Véronique; Gras, Thierry; Bruyère, Céline; Dubois, Jacques; Mathieu, Véronique; Kornienko, Alexander; Kiss, Robert; Evidente, Antonio
Informations sur la publication:Journal of medicinal chemistry, 52, 20, page (6244-6256)
Statut de publication:Publié, 2009-10
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Actins -- metabolism
Amaryllidaceae Alkaloids -- chemistry
Amaryllidaceae Alkaloids -- pharmacology
Amaryllidaceae Alkaloids -- therapeutic use
Amaryllidaceae Alkaloids -- toxicity
Animals
Antineoplastic Agents -- chemistry
Antineoplastic Agents -- pharmacology
Antineoplastic Agents -- therapeutic use
Antineoplastic Agents -- toxicity
Apoptosis -- drug effects
Cell Movement -- drug effects
Cell Proliferation -- drug effects
Cytoskeleton -- drug effects
Cytoskeleton -- metabolism
Drug Resistance, Neoplasm -- drug effects
Female
Humans
Inhibitory Concentration 50
Maximum Tolerated Dose
Melanoma -- drug therapy
Mice
Phenanthridines -- chemistry
Phenanthridines -- pharmacology
Phenanthridines -- therapeutic use
Phenanthridines -- toxicity
Structure-Activity Relationship
Xenograft Model Antitumor Assays
Note générale:Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0022-2623
info:doi/10.1021/jm901031h
info:scp/70350068068
info:pmid/19788245

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