Titre :
  • Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Auteur : Lamoral-Theys, Delphine ; Andolfi, Anna ; Van Goietsenoven, Gwendoline ; Cimmino, Alessio ; Le Calve, Benjamin ; Wauthoz, Nathalie ; Megalizzi, Véronique ; Gras, Thierry ; Bruyère, Céline ; Dubois, Jacques ; Mathieu, Véronique ; Kornienko, Alexander ; Kiss, Robert ; Evidente, Antonio
Informations sur la publication : Journal of medicinal chemistry, 52, 20, (page 6244-6256)
Statut de publication : Publié, 2009-10
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Actins -- metabolism
Amaryllidaceae Alkaloids -- chemistry
Amaryllidaceae Alkaloids -- pharmacology
Amaryllidaceae Alkaloids -- therapeutic use
Amaryllidaceae Alkaloids -- toxicity
Animals
Antineoplastic Agents -- chemistry
Antineoplastic Agents -- pharmacology
Antineoplastic Agents -- therapeutic use
Antineoplastic Agents -- toxicity
Apoptosis -- drug effects
Cell Movement -- drug effects
Cell Proliferation -- drug effects
Cytoskeleton -- drug effects
Cytoskeleton -- metabolism
Drug Resistance, Neoplasm -- drug effects
Female
Humans
Inhibitory Concentration 50
Maximum Tolerated Dose
Melanoma -- drug therapy
Mice
Phenanthridines -- chemistry
Phenanthridines -- pharmacology
Phenanthridines -- therapeutic use
Phenanthridines -- toxicity
Structure-Activity Relationship
Xenograft Model Antitumor Assays
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm901031h
info:pmid/19788245