Titre :
  • Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.
Auteur : Liu, D ; Cardozo, Alessandra K ; Darville, Martine ; Eizirik, Decio L.
Informations sur la publication : Endocrinology, 143, 4, (page 1225-1234)
Statut de publication : Publié, 2002
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Adenoviridae Infections -- pathology
Animals
Apoptosis -- physiology
Cell Death -- drug effects
Cells, Cultured
Chemokines -- biosynthesis
Chemokines -- physiology
Cytokines -- biosynthesis
Diabetes Mellitus, Type 1 -- physiopathology
Diabetes Mellitus, Type 1 -- virology
Fas Ligand Protein
Insulin -- biosynthesis
Interferon-gamma -- pharmacology
Interleukin-1 -- pharmacology
Islets of Langerhans -- drug effects
Islets of Langerhans -- metabolism
Islets of Langerhans -- pathology
Luciferases -- metabolism
Male
Membrane Glycoproteins -- biosynthesis
Membrane Glycoproteins -- pharmacology
NF-kappa B -- physiology
Poly I-C -- pharmacology
RNA, Double-Stranded -- physiology
RNA, Messenger -- biosynthesis
RNA, Messenger -- isolation & purification
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Transfection
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0013-7227 
info:pmid/11897677