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Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

par Liu, D;Cardozo, Alessandra K ;Darville, Martine ;Eizirik, Decio L.
Référence Endocrinology, 143, 4, page (1225-1234)
Publication Publié, 2002

Article révisé par les pairs

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Titre:	Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.
Auteur:	Liu, D; Cardozo, Alessandra K; Darville, Martine; Eizirik, Decio L.
Informations sur la publication:	Endocrinology, 143, 4, page (1225-1234)
Statut de publication:	Publié, 2002
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenoviridae Infections -- pathology
	Animals
	Apoptosis -- physiology
	Cell Death -- drug effects
	Cells, Cultured
	Chemokines -- biosynthesis
	Chemokines -- physiology
	Cytokines -- biosynthesis
	Diabetes Mellitus, Type 1 -- physiopathology
	Diabetes Mellitus, Type 1 -- virology
	Fas Ligand Protein
	Insulin -- biosynthesis
	Interferon-gamma -- pharmacology
	Interleukin-1 -- pharmacology
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- metabolism
	Islets of Langerhans -- pathology
	Luciferases -- metabolism
	Male
	Membrane Glycoproteins -- biosynthesis
	Membrane Glycoproteins -- pharmacology
	NF-kappa B -- physiology
	Poly I-C -- pharmacology
	RNA, Double-Stranded -- physiology
	RNA, Messenger -- biosynthesis
	RNA, Messenger -- isolation & purification
	Rats
	Rats, Wistar
	Reverse Transcriptase Polymerase Chain Reaction
	Transfection
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0013-7227
	info:pmid/11897677