Titre :
  • Inhibition of hIAPP Amyloid Aggregation and Pancreatic β-Cell Toxicity by OH-Terminated PAMAM Dendrimer.
Auteur : Gurzov, Esteban Nicolas ; Wang, Bo B ; Pilkington, Emily H EH ; Chen, Pengyu P ; Kakinen, Aleksandr A ; Stanley, William J WJ ; Litwak, Sara A SA ; Hanssen, Eric G EG ; Davis, Thomas P TP ; Ding, Feng F ; Ke, Pu Chun PC
Informations sur la publication : Small, 12, 12, (page 1615-1626)
Statut de publication : Publié, 2016-03
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : amyloid fibrillation
cytotoxicity
discrete molecular dynamics simulations
high-throughput dynamic light scattering
human islet amyloid polypeptide
hydroxyl-terminated polyamidoamine dendrimer
protein aggregation
Mots-clés MeSH : Amyloid -- metabolism
Cell Death -- drug effects
Cytoprotection -- drug effects
Dendrimers -- toxicity
Humans
Hydroxylation
Insulin-Secreting Cells -- drug effects -- pathology
Islet Amyloid Polypeptide -- metabolism
Models, Molecular
Protein Aggregates -- drug effects
Protein Multimerization -- drug effects
Thiazoles -- metabolism
Langue :
  • Anglais
Identificateurs : urn:issn:1613-6810 
info:doi/10.1002/smll.201502317
info:pmid/26808649