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Dexamethasone bovine pharmacokinetics

par Gaignage, Ph;Lognay, Georges C.;Bosson, Danièle ;Vertongen, D.;Dreze, Ph;Marlier, Michel;Severin, Michel
Référence European journal of drug metabolism and pharmacokinetics, 16, 3, page (219-221)
Publication Publié, 1991-07

Article révisé par les pairs

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Résumé :

Dexamethasone phosphate (DXM-PHO) is an ester which is quickly hydrolysed by the bovine and the dexamethasone (DXM) plasma half-life was 5.16 h. It has been demonstrated that 54h after DXM-PHO injection, DXM concentrations were lower than 0.1 mg/ml. Tritiated dexamethasone was also administered twice to an another young bull for metabolite investigation. The elapsed time required to recover, in plasma, half of the radioactivity injected was 8.8h. Radioactivity recovery in the urine reached 36.4% and 22.6% for the first and the second injections respectively. © 1991 Springer-Verlag.