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Postoperative gastric ileus

par Dubois, André ;Watanabe, August A.M.;Kopin, Irwin I.J.
Référence American Journal of Digestive Diseases, 18, 1, page (39-42)
Publication Publié, 1973-01

Article révisé par les pairs

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Résumé :

Gastric emptying was measured in healthy, trained, unanesthetized dogs before and after surgical manipulation of the intestine and/or treatment with bretylium. Gastric content was found to decline exponentially with time. The pattern of emptying could be defined by the volume remaining in the stomach 10 minutes after the start of feeding and by the slope of the exponential decline in volume of the contents (the rate of gastric emptying). Laparotomy with intestinal manipulation induced gastric retention, but laparotomy alone (sham operation) did not change the rate of gastric emptying. Bretylium, an adrenergic blocking drug, suppressed the postoperative gastric ileus without significantly altering gastric emptying in control animals. Our observations support the classical assumption of a sympathetic hyperactivity during postoperative ileus and suggest that adrenergic blocking agents may be useful in the treatment of paralytic ileus. © 1973 Medical Department Harper & Row, Publishers, Inc.