par Kinnear, William;Higenbottam, Timothy;Shaw, Doug;Wallwork, John;Estenne, Marc 
Référence Respiration physiology, 77, 1, page (75-88)
Publication Publié, 1989
Référence Respiration physiology, 77, 1, page (75-88)
Publication Publié, 1989
Article révisé par les pairs
| Résumé : | We have studied the contribution of vagal pulmunary receptors to the stability of breathing during postural changes in humans. Quiet breathing was quantified in the seated and the supine postures in 10 patients with chronic pulmunary denervation due to heart-lung transplantation and 10 age and sex matched normal controls. In the vast majority of patients and normal subjects frequency histograms for tidal volume and mean inspiratoru flow rate were virtually superimposed seated and supine. There were no significant differences in the mean levels of respiratory variables between postures in either group (except for mean inspiratory flow rate in the patients which was slightly greater seated than supine). Experiments performed on a tilt table in two additional patients showed that the ventilatory response to postural changes was immediate. In addition, the response was maintained after blockade of intact tracheal stretch receptors with aerosolized lidocaine. These results indicate that adequate ventilatory compensation during postural changes does not depend on vagal afferent information arising in intrapulmonary or tracheal airway stretch receptors. The appropriate receptors may be diaphragmatic Golgi tendon organs. © 1989. |
