par Spapen, H.;Zhang, Han ;Wisse, E;Baekeland, Marijke;Seynaeve, Carine;Eddouks, M;Vincent, Jean Louis
Référence The Journal of surgical research, 86, 2, page (183-191)
Publication Publié, 1999-10
Référence The Journal of surgical research, 86, 2, page (183-191)
Publication Publié, 1999-10
Article révisé par les pairs
Résumé : | 21-Aminosteroids are potent anti-inflammatory and antioxidant drugs that provide remarkable endothelial protection in different models of tissue ischemia-reperfusion and inflammation. The effects of 21-aminosteroids in sepsis, a highly inflammatory condition leading to panendothelial activation and injury, are largely uninvestigated. We therefore explored the effects of the 21-aminosteroid U74386G on hepatic blood flow, endothelial cell function, and sinusoidal structure in a canine model of fluid-resuscitated, hyperdynamic endotoxic shock. |