Titre:
  • Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy.
Auteur:Hubaux, Roland; Vandermeers, Fabian; Crisanti, M Cecilia; Crisanti, Cecilia; Kapoor, Veena; Burny, Arsène; Mascaux, Céline; Albelda, Steven M; Willems, Lucas
Informations sur la publication:European journal of cancer, 46, 9, page (1724-1734)
Statut de publication:Publié, 2010-06
Sujet CREF:Cancérologie
Mots-clés:Chemotherapy
HDAC
Mice
Small cell lung cancer
Valproate
MeSH keywords:Animals
Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
Apoptosis -- drug effects -- genetics
Blotting, Western
Caspases -- metabolism
Cell Line, Tumor
Cell Proliferation -- drug effects
Cisplatin -- administration & dosage
Drug Synergism
Etoposide -- administration & dosage
Female
Gene Expression -- drug effects
Histone Deacetylase Inhibitors -- therapeutic use
Humans
Lung Neoplasms -- drug therapy
Mice
Mice, SCID
Microarray Analysis
Neoplasm Transplantation
Small Cell Lung Carcinoma -- drug therapy
Transplantation, Heterologous
Valproic Acid -- therapeutic use
Note générale:Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0959-8049
info:doi/10.1016/j.ejca.2010.03.021
info:pii/S0959-8049(10)00252-2
info:scp/77952582492
info:pmid/20451370