par Arcos-Ortiz, Alexandra 
Président du jury Van Melderen, Laurence
Promoteur de Kerchove d'Exaerde, Alban
Publication Non publié, 2024-08-28
Président du jury Van Melderen, Laurence
Promoteur de Kerchove d'Exaerde, Alban
Publication Non publié, 2024-08-28
Mémoire
| Résumé : | Maged1 is a gene that belongs to the Melanoma-Associated Antigen (Mage) family. It isubiquitously expressed in healthy tissues during development and adulthood. Maged1knockout mice exhibit behavioral alterations such as depressive-like phenotypes, motorlearning difficulties, obesity, anxiety, and disrupted circadian rhythms. More recently,research from my host laboratory has shown that this gene plays a role in drug addiction.Specifically, Maged1 KO mice do not exhibit locomotor sensitization or response after drugadministration. It has also been shown that the paraventricular thalamic nucleus (PVT) is thekey region where Maged1 plays its role in addiction, particularly in neurons expressing VgluT2.The laboratory of C. Lüscher developed a model mimicking the transition to a compulsivestate, demonstrating that self-stimulation of DA neurons in the VTA is sufficient to triggerbehavior similar to compulsive drug use. In this study, we replicated this experiment toinvestigate Maged1's role in compulsion. Our results suggest that Maged1 is not involved inthe establishment and maintenance of self-stimulation. Regarding cocaine-induced locomotorsensitization, Maged1 does not appear to play a role in the maintenance of addiction. Finally,the interaction between Maged1 and Praja, two of its partner proteins, does not seemnecessary for cocaine-induced behaviors. |
