Article révisé par les pairs
Titre:
  • A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Auteur:Takacs, Zoltan; Toups, Megan; Kollewe, Astrid; Johnson, Erik; Cuello, Luis G; Driessens, Grégory; Biancalana, Matthew; Koide, Akiko; Ponte, Cristiano G; Perozo, Eduardo; Gajewski, Thomas F.; Suarez-Kurtz, Guilherme; Koide, Shohei; Goldstein, Steve A N
Informations sur la publication:Proceedings of the National Academy of Sciences of the United States of America, 106, 52, page (22211-22216)
Statut de publication:Publié, 2009-12
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Amino Acid Sequence
Animals
Cytokines -- biosynthesis
Drug Design
Female
Humans
Kv1.3 Potassium Channel -- antagonists & inhibitors -- genetics
Ligands
Models, Molecular
Molecular Sequence Data
Neurotoxins -- chemistry -- genetics -- pharmacology
Oocytes -- drug effects -- metabolism
Peptide Library
Peptides -- chemistry -- pharmacology
Potassium Channel Blockers -- chemistry -- pharmacology
Protein Engineering
Rats
Recombinant Proteins -- antagonists & inhibitors -- genetics
Scorpion Venoms -- chemistry -- genetics -- pharmacology
T-Lymphocytes -- drug effects -- immunology -- metabolism
Xenopus laevis
Note générale:In Vitro
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0027-8424
info:doi/10.1073/pnas.0910123106
info:pii/0910123106
info:pmid/20007782
PMC2799710

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