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Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.

par Vandurm, Pierre;Guiguen, Allan ;Cauvin, Christine;Georges, Benoît;Le Van, Kiet ;Michaux, Catherine;Cardona, Christelle ;Mbemba, Gladys;Mouscadet, Jean-François;Hevesi, László;Van Lint, Carine ;Wouters, Johan
Référence European journal of medicinal chemistry, 46, 5, page (1749-1756)
Publication Publié, 2011

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Titre:	Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.
Auteur:	Vandurm, Pierre; Guiguen, Allan; Cauvin, Christine; Georges, Benoît; Le Van, Kiet; Michaux, Catherine; Cardona, Christelle; Mbemba, Gladys; Mouscadet, Jean-François; Hevesi, László; Van Lint, Carine; Wouters, Johan
Informations sur la publication:	European journal of medicinal chemistry, 46, 5, page (1749-1756)
Statut de publication:	Publié, 2011
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Anti-integrase activity
	Antiviral activity
	Docking
	HIV-1 IN
	Molecular modeling
	Quinolonyl diketo acid
MeSH keywords:	Anti-HIV Agents -- chemical synthesis -- chemistry -- pharmacology
	Catalytic Domain -- drug effects
	Dose-Response Relationship, Drug
	Drug Design
	HIV -- drug effects
	HIV Integrase -- chemistry -- metabolism
	HIV Integrase Inhibitors -- chemical synthesis -- chemistry -- pharmacology
	Keto Acids -- chemical synthesis -- chemistry -- pharmacology
	Models, Molecular
	Molecular Structure
	Quinolones -- chemical synthesis -- chemistry -- pharmacology
	Stereoisomerism
	Structure-Activity Relationship
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0223-5234
	info:doi/10.1016/j.ejmech.2011.02.028
	info:pii/S0223-5234(11)00139-5
	info:scp/79953202832
	info:pmid/21385662