par Fall, Ahmedou Bamba Koueimel 
;Toppet, Michèle ;Ferster, Alina ;Fondu, Pierre ;Vanhaelen Fastré, Renée ;Vanhaelen, Maurice
Référence British journal of haematology, 103, 4, page (957-959)
Publication Publié, 1998-12
;Toppet, Michèle ;Ferster, Alina ;Fondu, Pierre ;Vanhaelen Fastré, Renée ;Vanhaelen, Maurice Référence British journal of haematology, 103, 4, page (957-959)
Publication Publié, 1998-12
Article révisé par les pairs
| Résumé : | The improvement in sickle cell disease (SCD) children receiving cromolyn sodium therapy prompted us to investigate its antisickling activity in vitro. The number of sickle cells was determined in deoxygenated blood samples from 15 children with severe SCD. At the eight concentrations tested, cromolyn sodium exhibited a significantly higher activity than pentoxifylline, the standard compound. Therefore cromolyn sodium would appear to be an interesting candidate for SCD therapy and deserves further in vivo investigations. |
