par Caufriez, Anne 
;Moreno Reyes, Mario Rodrigo ;Leproult, Rachel ;Vertongen, Françoise ;Van Cauter, Eve ;Copinschi, Georges
Référence American journal of physiology: endocrinology and metabolism, 282, 5, page (1147-1153)
Publication Publié, 2002
;Moreno Reyes, Mario Rodrigo ;Leproult, Rachel ;Vertongen, Françoise ;Van Cauter, Eve ;Copinschi, Georges Référence American journal of physiology: endocrinology and metabolism, 282, 5, page (1147-1153)
Publication Publié, 2002
Article révisé par les pairs
| Résumé : | To investigate the adaptation of plasma cortisol profiles to an abrupt phase advance of the rest-activity cycle, eight normal young subjects were submitted in a sleep laboratory to an 8-h advance shift of their sleep-wake and dark-light cycles. The shift was achieved by advancing bedtimes from 2300-0700 to 1500-2300, Blood samples were obtained at 20-min intervals for 68 consecutive hours. The shift resulted within 6-9 h in a 3- to 4-h advance of timings of the nadir of the cortisol profile and of the end of the quiescent period but had no immediate effect on the timing of cortisol acrophase. The quiescent period of cortisol secretion was shortened and fragmented. Thus a major advance shift achieved without enforcing sleep deprivation results in a rapid partial adaptation of the temporal profiles of cortisol but also in a marked disruption of the cortisol quiescent period. Sleep onset was consistently followed by a decrease in cortisol concentrations. Conversely, both sleep-wake and dark-light transitions were consistently associated with cortisol secretory pulses. |
