• Citer

Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4.

par Szpirer, Claude ;Szpirer, Josiane ;Riviere, Michèle ;Swinnen, Johan;Vicini, E;Conti, M
Référence Cytogenetics and cell genetics, 69, 1-2, page (11-14)
Publication Publié, 1995

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Through the use of somatic cell hybrids segregating either human or rat chromosomes, we determined the chromosome localizations of two genes encoding cAMP-specific phosphodiesterases (cAMP-PDEs). PDE4D, the gene encoding the cAMP-PDE isoform 3 (IVd), was assigned to human chromosome 5 and rat chromosome 2, and PDE4B, the gene encoding the cAMP-PDE isoform 4 (IVb), was assigned to human chromosome 1 and rat chromosome 5. These localizations extend the homology between rat chromosome 2 and human chromosome 5, on the one hand, and between rat chromosome 5 and human chromosome 1, on the other hand.