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The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7.

par Szpirer, Josiane ;Szpirer, Claude ;Riviere, Michèle ;Levan, Göran;Marynen, Peter;Cassiman, J J;Wiese, R;DeLuca, H F
Référence Genomics, 11, 1, page (168-173)
Publication Publié, 1991-09

Article révisé par les pairs

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Résumé :

By means of somatic cell hybrids segregating either human or rat chromosomes, the genes encoding the transcription factor Sp1 (SP1) and the 1,25-dihydroxyvitamin D3 receptor (VDR) were both assigned to human chromosome arm 12q and to rat chromosome 7. This result implies that the locus for the clinical disorder vitamin D dependency rickets type II maps on 12q. The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-gamma (RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating that a synteny group is conserved on these chromosomes.