par Brasseur, Robert ;Deleers, Michel
Référence Pharmacological research communications, 15, 10, page (901-907)
Publication Publié, 1983-11
Article révisé par les pairs
Résumé : Theoretical conformational analysis has been carried out for different hypoglycemic sulfonylurea -Ca complexes. The formed complex has an hydrophobic external surface and a low amphiphilic character. Our results suggest that Calcium may effectively be transported across membranes of Langerhans B cells and that the different biological potencies of the drugs may be due in part to the shape of the different complexes.

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