par Deleers, Michel ;Brasseur, Robert
Référence Pharmacological research communications, 18, 2, page (129-136)
Publication Publié, 1986-02
Article révisé par les pairs
Résumé : The ability of glibenclamide and of gliclazide to act as protonophores has been studied in black lipid membranes made of glycerol monoleate as a function of pH and drug concentration. Protons may effectively be transported across lipid membranes with a maximum at a pH close to the pKa of the sulfamide (pKa of glibenclamide = 5.4). It is suggested therefore that hypoglycemic sulfonylureas may act in part as Ca2+ inward and H+ outward ionophores through plasma membranes of pancreatic B cells.