The dopamine D1 receptor antagonist SCH-23390 decreases the mRNA levels of the transcription factor zif268 (krox-24) in adult rat intact striatum - An in situ hybridization study

Mailleux, Pierre; Zhang, F.; Vanderhaeghen, Jean-Jacques

doi:doi/10.1016/0304-3940(92)90590-4

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The dopamine D1 receptor antagonist SCH-23390 decreases the mRNA levels of the transcription factor zif268 (krox-24) in adult rat intact striatum - An in situ hybridization study

par Mailleux, Pierre

;Zhang, F.;Vanderhaeghen, Jean-Jacques

Référence Neuroscience letters, 147, 2, page (182-184)
Publication Publié, 1992

Article révisé par les pairs

Résumé :

By in situ hybridization with an oligonucleotide probe, we have studied the cellular distribution of the messenger RNA encoding the transcription factor zif268 (krox-24) in the adult intact rat striatum and regulation of its synthesis by acute treatment with the dopamine D1 receptor antagonist SCH-23390. Zif268 mRNA was found in the striatal medium-sized neurons and not in the large cells. Its levels were decreased by SCH-23390, suggesting activation of this immediate early gene in the striatum through dopamine D1 receptor stimulation.

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