par Mailleux, Pierre 
;Vanderhaeghen, Jean-Jacques
Référence European Journal of Pharmacology - Molecular Pharmacology Section, 266, 2, page (193-196)
Publication Publié, 1994
;Vanderhaeghen, Jean-Jacques Référence European Journal of Pharmacology - Molecular Pharmacology Section, 266, 2, page (193-196)
Publication Publié, 1994
Article révisé par les pairs
| Résumé : | Glutamatergic regulation of δ-9-tetrahydrocannabinol (THC) receptor gene expression in the adult rat dorsal striatum following a 2 week unilateral cerebral decortication or pharmacological treatment with MK-801 was investigated by quantitative in situ hybridization. The caudate-putamen on the side of the cerebral decortication contains about 30% significantly lower mRNA levels than the control. In addition, we observed a 52% significant decrease in THC receptor mRNA levels in intact dorsal striatum after treatment with MK-801. Together these results suggest that in vivo, through the NMDA receptor subtype, glutamate up-regulates THC receptor gene expression in the rat caudate-putamen. |
