par Hardy, Olivier J. 
;Charbonnel, N;Fréville, H.;Heuertz, Myriam
Référence Genetics, 163, page (1467-1482)
Publication Publié, 2003
;Charbonnel, N;Fréville, H.;Heuertz, Myriam Référence Genetics, 163, page (1467-1482)
Publication Publié, 2003
Article révisé par les pairs
| Résumé : | The mutation process at microsatellite loci typically occurs at high rates and with stepwise changes in allele sizes, features that may introduce bias when using classical measures of population differentiation based on allele identity (e.g., F-ST, Nei's Ds genetic distance). Allele size-based measures of differentiation, assuming a stepwise mutation process [e.g., Slatkin's R-ST, Goldstein et al.'s may better reflect differentiation at microsatellite loci, but they suffer high sampling variance. The relative efficiency of allele size- vs. allele identity-based statistics depends on the relative contributions of mutations vs. drift to population differentiation. We present a simple test based on a randomization procedure of allele sizes to determine whether stepwise-like mutations contributed to genetic differentiation. This test can be applied to arty microsatellite data set designed to assess population differentiation and can be interpreted as testing whether F-ST |
