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In vitro effects of organotin-substituted steroids in human tumor cell lines

par Gielen, Marcel ;Lelieveld, Peter;De Vos, Danièle ;Pan, Huade;Willem, Rudolph ;Biesemans, Monique;Fiebig, H.H.
Référence Inorganica Chimica Acta, 196, page (115-117)
Publication Publié, 1992

Article révisé par les pairs

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Résumé :

Four steroidal organotin compounds have been prepared and compared in vitro with a parent steroid and two model compounds in a series of human tumor cell lines. The organotin steroids (compounds 1 and 2) showed promising in vitro activity. Another compound with important characteristics in terms of bond angles and stereochemistry (compound 3) was a highly effective antitumor agent. This compound may serve as a model for further investigation on the structure-activity relationship in antitumor organotin compounds. © 1992.