par Nguyen, Anh Tho 
;Fontaine, Jeanine ;Malonne, Hugues ;Claeys, Magda;Luhmer, Michel ;Duez, Pierre
Référence Phytochemistry, 66, 10, page (1186-1191)
Publication Publié, 2005-05
;Fontaine, Jeanine ;Malonne, Hugues ;Claeys, Magda;Luhmer, Michel ;Duez, Pierre Référence Phytochemistry, 66, 10, page (1186-1191)
Publication Publié, 2005-05
Article révisé par les pairs
| Résumé : | From cytotoxic extracts of the roots of Scrophularia ningpoensis Hemsl. (Scrophulariaceae) a new sugar ester, ningposide D (3-O-acetyl-2-O-p- methoxycinnamoyl-α(β)-l-rhamnopyranose) (1) and a new iridoid glycoside, scrophuloside B4 (6-O-(2″-O-acetyl-3″-O- cinnamoyl-4″-O-p-methoxycinnamoyl-α-l-rhamnopyranosyl) catalpol) (2) along with known compounds: oleanonic acid (3), ursolonic acid (4), cinnamic acid (5), 3-hydroxy-4-methoxy benzoic acid (6), 5-(hydroxymethyl)-2-furfural (7) and β-sitosterol (8) were isolated. The structures of the new compounds were elucidated by spectral data (1, 2D NMR, EI, HRESI-MS and MS/MS). Oleanonic acid (3) and ursolonic acid (4) were found to be cytotoxic against a series of human cancer cell lines with IC50 = 4.6, 15.5 μM on MCF7; 4.2, 14.5 μM on K562; 14.8, 44.4 μM on Bowes; 24.9, 43.6 μM on T24S; 61.3, 151.5 μM on A549, respectively. β-Sitosterol (8) inhibited Bowes cells growth at IC50 = 36.5 μM. Scrophuloside B4 (2) showed activity on K562 and Bowes cells at IC50 = 44.6, 90.2 μM, respectively. © 2005 Elsevier Ltd. All rights reserved. |
