Résumé : The isotopic abundances of neon, iron, and a number of other species in the galactic cosmic rays have been measured using the Cosmic Ray Isotope Spectrometer (CRIS) aboard the NASA Advanced Composition Explorer (ACE) spacecraft. We compare our data to results from two-component Wolf-Rayet (WR) models. The largest deviations of galactic cosmic ray (GCR) isotope ratios from solar-system ratios predicted by these models are 12C/16O, 22Ne/20Ne, and 58Fe/56Fe. Our measured abundance ratios show good agreement with the model predictions. All of our measured isotopic ratios are consistent with a GCR source consisting of ∼20% of WR material mixed with ∼80% material with solar-system composition. Since WR stars are evolutionary products of OB stars, and most OB stars exist in OB associations, the good agreement of our data with these models strongly suggests that OB associations are the most probable source of at least a substantial fraction of GCRs. In previous work we have shown that the primary 59Ni (which is radioactive and decays only by electron-capture) synthesized in supernovae has decayed prior to being accelerated to GCRs, indicating a time interval between nucleosynthesis and acceleration of >105 yr. In this paper we describe a scenario that should allow most of the 59Ni to decay in the OB association environment and conclude that OB associations are the likely source of most GCRs. © 2008 Elsevier B.V.