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Effects of AMI-25 on liver vessels and tumors on T1-weighted turbo-field-echo images: Implications for tumor characterization

par Van Gansbeke, Daniel ;Metens, Thierry ;Matos Pinto De Almeida, Celso ;Nicaise, Nicole ;Gay, France ;Raeymaekers, Hubert;Struyven, Julien
Référence Journal of magnetic resonance imaging, 7, 3, page (482-489)
Publication Publié, 1997-06

Article révisé par les pairs

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Résumé :

This study was devoted to tumor differentiation in liver MR T1-weighted imaging with superparamagnetic iron oxide (SPIO). Twenty-one patients with 40 liver lesions were studied at 1.5 T. Before and at least 45 minutes after SPIO administration, turbo-field-echo (TFE) T1-weighted, TFE T1 × T2*-weighted (MXT), and fat-suppressed turbo-spin-echo T2-weighted images were acquired. A quantitative analysis was performed blindly. On TFE T1-weighted images, the signal enhancement was −33% ± 12 for the liver, −24% ± 2 for adenomas and focal nodular hyperplasia, +60% ± 33 for the hemangiomas; metastases and cyst enhancement were not significant. After SPIO on TFE T1-weighted images, the hemangioma-to-liver signal ratio (149% ± 18) was definitely higher than the mean metastasis-to-liver signal ratio (90% ± 16). This T1-related differentiation ability lacked dramatically on TFE MXT images and, in one case, was reduced on post-SPIO TFE T1-weighted images by a long imaging delay after SPIO administration (2 hours).