Induction of autoanti-idiotypic antibodies and effects of the subsequent immune response

Wuilmart, Christian; Wikler, Maurice Mosze; Urbain, Jacques

doi:doi/10.1016/0161-5890(79)90042-7

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Induction of autoanti-idiotypic antibodies and effects of the subsequent immune response

par Wuilmart, Christian

;Wikler, Maurice Mosze

;Urbain, Jacques

Référence Molecular immunology, 16, 12, page (1085-1092)
Publication Publié, 1979

Article révisé par les pairs

Résumé :

Rabbits hyperimmunized with Micrococcus luteus produce two unrelated antibody populations of restricted affinity. After isolation, one specific Ab population was subjected to preparative isoelectric focusing and one single isoelectric fraction was used to induce iso- and autoanti-idiotypic antibodies. It is shown that individual rabbits are able to synthesize antibodies directed against their own idiotypic determinants. Moreover, such an induction of autoanti-idiotypic antibodies is shown to modulate the idiotypic expression when the animal is subsequently restimulated by the original antigen.

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