par Carpentier, Yvon 
;Richelle, Myriam ;Rubin, Moshe;Rössle, Claudia;Dahlan, Winai ;Bosson, W.;Furst, Peter
Référence Clinical nutrition, 9, 6, page (313-318)
Publication Publié, 1990
;Richelle, Myriam ;Rubin, Moshe;Rössle, Claudia;Dahlan, Winai ;Bosson, W.;Furst, PeterRéférence Clinical nutrition, 9, 6, page (313-318)
Publication Publié, 1990
Article révisé par les pairs
| Résumé : | Metabolic studies involving changes in plasma substrate concentrations are frequently carried out after an overnight fast. This condition, however, is a transition between the post-prandial period and the beginning of starvation, and thus is associated with rapid changes in the plasma concentration of many substrates. Such alterations might interfere with the interpretation of modifications in plasma concentrations resulting from experimental manipulations. Infusion of glucose at a rate of 250 mg kg-1 h-1 for 1 h and subsequently at 162 mg kg-1 h-1 together with amino-acids at 50 mg-1 h-1 is used to stabilise the plasma concentration of most substrates within 3 h, a condition which is maintained for the subsequent 5h or more. This study offers a model which is more suitable for many metabolic investigations than overnight fasting takes little time or expense to prepare. |
