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Di-n-butyl-, tri-n-butyl- and triphenyltin steroidcarboxylates: synthesis, NMR characterization and in vitro antitumour activity

par Willem, Rudolph ;Dalil, Hassan ;Broekaert, Paul ;Biesemans, Monique;Ghys, L.;Nooter, K;De Vos, Danièle ;Ribot, F.;Gielen, Marcel
Référence Main group metal chemistry, 20, 8, page (535-542)
Publication Publié, 1997

Article révisé par les pairs

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Résumé :

A series of tri- and diorganotin steroidcarboxylates were synthesized and characterized by 1D and 2D 1H, 13C, 117Sn and 1H-13C HMQC and HMBC NMR spectroscopy as well as by 119Sn MAS NMR. The in vitro antitumour activities of the di-n-butyltin compound 1 against seven human tumour cell lines, MCF-7 and EVSA-T, two breast cancers, WiDr, a colon cancer, IGROV, an ovarian cancer, M19 MEL, a melanoma, A498, a renal cancer, and H226, a non small cell lung cancer lie between those of 5-fluorouracil and doxorubicin. The activities of the triorganotin compounds 6, 7, 9 and 11 are comparable to those of methotrexate or doxorubicin.