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Crystal structure and in vitro antitumour activity of dibutylbis(5-chloro-2-hydroxybenzoato)tin(IV)

par Gielen, Marcel ;Boualam, Mohammed ;Mahieu, Bernard;Tiekink, Edward
Référence Applied organometallic chemistry, 8, 1, page (19-23)
Publication Publié, 1994

Article révisé par les pairs

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Résumé :

The crystal structure of the title compound, [nBu2Sn(5-Cl-2-OH-C6H3CO2)2], shows that in the monomeric species the six-coordinate Sn atom exists in a skew trapezoidal bipyramidal geometry in which the four O donor atoms, derived from two asymmetrically chelating carboxylate ligands, define the basal plane and the n-butyl substituents lie over the weaker Sn[BOND]O interactions defining a C[BOND]Sn[BOND]C angle of 147.6(2)°. An unusual feature of the structure is the presence of both intra- and inter-molecular hydrogen bonding contacts which serve to stabilize the structure. The in vitro antitumour activity of this compound against mammary and colon carcinoma cell lines is also reported.