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Synthesis, characterization and in vitro antitumour activity of dimethyl-, diethyl-, and di-t-butyl-tin(IV) derivatives of substituted salicylic acids

par Boualam, Mohammed ;Willem, Rudolph ;Biesemans, Monique;Gielen, Marcel
Référence Applied organometallic chemistry, 5, 6, page (497-506)
Publication Publié, 1991-12

Article révisé par les pairs

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Résumé :

The synthesis of dimethyl-, diethyl- and/or di-t-butyl-tin(IV) derivatives of substituted salicylic acids of the type a, (X-Y-2-OH-C6H2COO)2SnR2 (X, Y [DOUBLE BOND] H, H; H, 5-CH3; H, 5-Cl; H, 5-F; H, 3-CH3O; H, 5-CH3O; 3-CH3, 6-(CH3)2CH; 3,5-[(CH3)2CH]2 and 4,5-benzo) and b {[R2(X-Y-2-OH-C6H2COO)Sn]2O}2 (X, Y [DOUBLE BOND] H, 3-CH3O; H, 5-CH3O: 3-CH3, 6-(CH3)2CH; 3,5-[(CH3)2CH]2 and 4,5-benzo) is reported. Their characterization by 1H, 13C and 119Sn NMR, Mössbauer and mass spectrometry is described. The in vitro antitumor activity of selected derivatives against two human tumoral cell lines, MCF-7 and WiDr, is presented.