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Synthesis, characterization and in vitro antitumour properties of complexes of bis(alkoxycarbonylmethyl)tin dibromides with bidentate nitrogen ligands

par Zhang, Zhongchun;Pan, Huade;Hu, C.;Sun, Yan;Willem, Rudolph ;Gielen, Marcel
Référence Applied organometallic chemistry, 5, 3, page (183-190)
Publication Publié, 1991-06

Article révisé par les pairs

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Résumé :

The synthesis and characterization of 10 new bis(;alkoxycarbonylmethyl)tin dibromides and of 14 of their complexes with bidentate nitrogen ligands (;bipyridyl, 1,10-phenanthroline and 5-nitro-1, 10-phenanthroline) are described. Their proton NMR spectra are discussed. Their in vitro antitumour activity against two human cancer cell lines, MCF-7 and WiDr, is low compared to antitumour drugs used clinically.