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Changes in plasma bradykinin concentration and citric acid cough threshold at high altitude.

par Mason, Nicholas ;Petersen, Merete;Melot, Christian ;Kim, Elena V;Aldashev, Almaz;Sarybaev, Akpay;Mirrakhimov, Mirsaid M.;Naeije, Robert
Référence Wilderness & environmental medicine, 20, 4, page (353-358)
Publication Publié, 2009

Article révisé par les pairs

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Résumé :

Altitude-related cough is a troublesome condition of unknown etiology. Inhaled tussive agents are used to quantify cough, and the citric acid cough threshold has been shown to fall on ascent to altitude. Cough can occur in patients taking angiotensin-converting enzyme inhibitors due to stimulation of airway sensory receptors by increased levels of bradykinin. We hypothesized that increased levels of bradykinin could be responsible for the decrease in citric acid cough threshold on exposure to altitude and a possible etiologic factor in altitude-related cough.