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New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation.

par Dewachter, Laurence ;Dewachter, Céline ;Naeije, Robert
Référence Expert opinion on investigational drugs, 19, 4, page (469-488)
Publication Publié, 2010-04

Article révisé par les pairs

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Résumé :

Treatments of pulmonary arterial hypertension (PAH) that have so far proven efficacious are all based on the restoration of endothelium control of pulmonary vascular tone and structure, by administration of prostacyclins, endothelin receptor antagonists and phosphodiesterase-5 inhibitors. However, results remain unsatisfactory, with persistent high mortality, insufficient clinical improvement and no convincing report of any reversal of the disease process.