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Automatic synthesis of [18F]altanserin, a radiopharmaceutical for positron emission tomographic studies of the serotonergic type-2 receptors

par Monclus, Michel ;Van Naemen, John ;Mulleneers, Eric ;Damhaut, Philippe;Luxen, André ;Goldman, Serge
Référence Clinical positron imaging : official journal of the Institute for Clinical P.E.T, 1, 2, page (111-116)
Publication Publié, 1998

Article révisé par les pairs

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Résumé :

[18F]Altanserin is routinely used in several centers to study the serotonergic type-2 receptors (5HT2) with positron emission tomography (PET). An automatic production system allowing the preparation of multimillicurie amounts [>1.5 GBq (40 mCi) EOS, mean radiochemical yield 20 = 6% EOB, specific activity >1 Ci/·mol (mean = 2.8 Ci/μmol) n = 50] of this radiopharmaceutical within a synthesis time of 90 minutes (quality controls included) is described in this paper. The apparatus includes the recovery of the activity from the target, the preparation of the dried [18F]KF/kryptofix 2.2.2 complex, the labeling reaction using a microwave cavity, the Sep Pak and HPLC purification. A sterile, pyrogen-free and single use unit was also developed for the formulation of the injectable solution. This last part could be used for the formulation of many other radiopharmaceuticals. Copyright © 1998 Elsevier Science Inc. All rights reserved.