par Bouhoute, Abdellah ;Leclercq, Guy
Référence Biochemical and biophysical research communications, 184, 3, page (1432-1440)
Publication Publié, 1992
Article révisé par les pairs
Résumé : Binding of (3H)-estradiol labeled estrogen receptor from uterine cytosol to calmodulin was demonstrated by both affinity chromatography and sucrose gradient sedimentation. Triphenylethylene antiestrogens (tamoxifen family) with strong antagonistic activity against the calmodulin-dependent c-AMP phosphodiesterase largely reduced the binding of the receptor. Relevance of this observation with regard to the major antiproliferative activity (cytotoxicity) of these drugs is discussed.

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