The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour

Top, Siden; Kaloun, El Bachir; Vessières, Anne; Laos, Ioanna; Leclercq, Guy; Jaouen, Gérard

doi:doi/10.1016/S0022-328X(01)01271-2

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The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour

par Top, Siden ;Kaloun, El Bachir ;Vessières, Anne ;Laos, Ioanna ;Leclercq, Guy

;Jaouen, Gérard
Référence Journal of organometallic chemistry, 643-644, page (350-356)
Publication Publié, 2002-02

Article révisé par les pairs

Résumé :

The synthesis of 4′, a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4′ is prepared by a McMurry coupling followed by a ligand exchange. Compound 4′ reveals an unexpected proliferative effect on the hormone-dependent cell line MCF7. Surprisingly this effect is also observed with Cp2TiCl2 alone. © 2002 Elsevier Science B.V. All rights reserved.

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