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Antifungal therapy in febrile neutropenic patients: Review of treatment choices and strategies for aspergillar infection

par Klastersky, Jean ;Paesmans, Marianne
Référence Supportive care in cancer, 15, 2, page (137-141)
Publication Publié, 2007-02

Article révisé par les pairs

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Résumé :

RATIONALE: Invasive fungal infections, especially aspergillosis, are a major problem in patients who undergo aggressive therapy for haematological malignancies. Presently, the standard therapy for demonstrated aspergillar infection is voriconazole. Because the morbidity and the mortality of proven aspergillar infection is relatively high, empirical and preemptive approaches have been explored. FINDINGS: Empirical therapy is effective at the cost of overtreatment in a significant number of patients. This can be reduced through the preemptive approach; however, its equivalence in terms of successful therapy and mortality should be studied further and, optimally, in prospective controlled clinical trials.