par Donnadieu, N.;Paesmans, Marianne ;Sculier, Jean-Paul
Référence Lung cancer, 7, 4, page (243-252)
Publication Publié, 1991
Article révisé par les pairs
Résumé : We have reviewed articles on chemotherapy trials in non-small cell lung cancer published over the last 15 years in order to determine by means of a meta-analysis whether the initial extent of tumour is a significant prognostic factor for treatment response. A total of 6247 patients were eligible for the analysis: 1435 with limited disease and 4812 with disseminated disease. The objective and complete response rates for the overall population were 25% and 3%, for the patients with limited disease 34% and 5%, and for those with disseminated disease 22% and 3% (P ≤ 0.001), respectively. The response rate was significantly lower for single agent chemotherapy than for combination chemotherapy. When applying combination chemotherapy, the best results were obtained with regimens containing cisplatin, vindesine, vinblastine, mitomycin C or ifosfamide. A high dose of cisplatin (≥100 mg/m2) was also associated with better response rates than a lower dose (≤70 mg/m2). These differences were often more marked in limited disease. In conclusion, this meta-analysis has established that limited disease is significantly associated with a higher objective rate than is disseminated disease. It has also given additional information useful for the design of future controlled trials in patients with non-small cell lung cancer.

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